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 Documentation on Amazon Herbs
 June 1999

Formula: Rainforest Treasure Tea

Statement: Potent recipe to provide you with balanced vitality and maximum clarity.

Documentation:

1 Screening for Antifungal Activity of Panamanian Plants by R.A. Halison et al. Int J Pharmacog 31, 1993 No. 1, 68-76. Jatoba (Hymenaea courbaril) and 152 other crude plant extracts were tested for antifungal activity against Candida albicans and Cladosporium cucmerinum. Activity was assessed in a semiquantitative fashion by bioautography on TLC plates. When tested at 100ug, Jatoba leaves-stem and also bark chloroform extract were effective against both fungi and Jatoba leaves-stem methanol was effective against Cladosporium cucmerium.


2 Medicinal Plants of Surinam IV by R. Verporrte and P.P. Dihal. Jour of Ethnopharm 21, 1987, 315-18. "The bark of Jatoba is active against Staphylococcus aureus and Bacillus subtilis."

3 U.S. Patent 5302, 611. April 12, 1994. Oxindole Alkaloids Having Properties Stimulating the Immunological System and Preparation Containing Same. Keplinger et al. "Tetra and pentacyclic oxindole alkaloids, in particular the alloisopteropodine, isomer A, a pentacyclic oxindole alkaloid, are suitable for the unspecific stimulation of the immunologic system, which has been proved by a substantial percentage phagocytosis increase in the granulocytic test according to BRANDT, a substantial percentage increase of the CL-response in the chemiluminescence test and a high increase of the phagocytosis activity of tissue macrophages of the reticuloendothelial system in the carbon clearance test according to BIOZZI. These alkaloids may be isolated from extracts of the roots of the Uncaria tomentosa whose fresh best has a yellow brown or dark red color, from which the tanning substances have largely been removed. The isopteropodine-containing roots showed values between 30 and 40% activity increase on the average. The examination of the raw alkaloid mixture in the water-soluble hydrochloride form showed an average phagocytosis increase of 20%."

4 New Quinovic Acid Glycosides from Uncaria tomentosa by Riccardo Cerri. J Nat Products, Vol. 51, No. 2, 257-261, Mar-Apr 1988. An aqueous and ethanolic extract of Uncaria tomentosa showed cytostatic activity. A number of alkaloids show a pronounced enhancement of phagocytosis.

5 Plant Metabolites. Structure and In Vitro Antiviral Activity of Quinovic Acid Glycosides from Uncaria tomentosa and Guettarda platypoda. J Nat Products, Vol. 52, No. 4, 1989, 679-685. A series of antiviral tests were performed on the quinovic acid glycosides in Uncaria tomentosa. The quinovic acid compounds inhibited vesicular stomatitis virus.

6 Die Alkaloide von Uncaria tomentosa und ihre Phagozytosesteigernde Wirkung by H. Wagner, B. Kreutzkamp and K. Jurcie, Planta Medica 1985, 419-423. "Of the six oxindole alkaloids isolated and identified from the roots of Uncaria tomentosa, all except mitraphyllin and rynchophyllin showed a pronounced enhancement of phagocytosis. This was determined in two in vitro tests and the in vivo carbon clearance test. The active alkaloids include isopteropodin, pteropodin, mitraphyllin, isomitraphyllin, rynchophyllin and isorynchophyllin."

7 Mutagenic and Antimutagenic Activities of Uncaria tomentosa and its Extracts. J Ethnopharm, Vol. 38, 1993, 63-77. Uncaria tomentosa plant extracts show a protective antimutagenic effect in vitro against photomutagenesis induced by 8-methoxypsoralen (8-MOP) plus UVA in S. typhirium TA 102. A decoction of U. tomentosa ingested daily for 15 days by a smoker decreased the mutagenicity induced in S. typhimurium TA 98 and TA100 by the subject's urine.

8 A Differential Sensitivity of Oxindole Alkaloids to Normal and Leukemic Cell Lines. Planta Medica, Vol. 59, 1993, A583. "All tested oxindole alkaloids dose-dependently inhibited the growth of HL60 and U-937 cells. The most pronounced effect was found for uncarine F with IC50 values (concentration required to inhibit 50% of the leukemic cells) of 21.7 (HL 60) and 29.0 (U 937) umol/1."

9 The Healing Power of Herbs, 2nd edition. By Michael Murray, 1995, 220-227. Pau d'Arco contains anthroquinones and naphthoquinones. The naphthoquinones are highly effective against Candida albicans and Tricophyton mentagrophytes.

10 A Lapachol Derivative Active Against Mouse Lymphocytic Leukemia P388 by M. da Consolamo et al. J Med Chem 18, 11, Nov 1975, 1159-61. "Lapachol and its derivatives were tested against rat tumor Walker 256 carcinosarcoma and found to be active. It was also effective against mouse lymphocytic leukemia P388."

11 Inhibition of Potentially Lethal DNA Damage Repair in Human Tumor Cells by Beta-laprachone, an Activator of Topoisomerase I by D.A. Boothman, D.K. Trask and A.B. Pardee. Cancer Research Vol. 49, No. 3, Feb 1, 1989, 605-12. "Beta-lapachone, found in Pau d'Arco, inhibited the fast component of potentially lethal damage repair carried out by HEP-2 cells when present during or immediately after x-irradiation. It does not further enhance the lethal effects of x-rays following prolonged drug exposures. The mechanism of action is through activation of topoisomerase I."  

12 Production of Anti-Tumor-Promoting Furanonaphthoquinones in Tabebuia avellandae Cell Cultures by S. Ueda et al. Phytochemistry Vol. 36, No. 2, 1994, 323-325. Tabebuia avellanedae (Tabebuia impetiginosa) quinones showed significant dose-dependent inhibitory effects in in vitro assays utilizing the activation of Epstein-Barr virus expression in EBV genome-carrying human lymphoblastoid cells to detect tumor promoters and anti-tumor promoters. These quinones have demonstrated potent cytotoxicity to human solid tumors in vitro. (A-549, MCF-7, HT-29)

13 Immunological Investigations of Naphthaquinone-containing Plant Extracts, Isolated Quinones and other Cytostatic Compounds in Cellular Immunosystems by H. Wagner, B. Kreher and K. Jurcie. Planta Med 1986 (6), 550-551, P99. "Pau d'Arco and other herb extracts were tested to see whether their well-known cytotoxic effects of the naphthaquinones were caused by a direct inhibition of the cell metabolism or by immuno-induced cytotoxicity. Most extracts and isolated compounds exerted in high concentrations (1 -0.01 mg/mL) a cytotoxic or immunosuppressive effect whereas the same preparations in very low concentration showed in nearly all cases immunostimulating properties. It was concluded that the induction of cellular and humoral immune factors was responsible for the action."  

14 The Honest Herbal by Varro Tyler, 1992. Pg. 239-241. "Lapachol does possess some anticancer properties. In 1968 it was shown to have significant activity against Walker 256 carcinosarcoma, particularly when administered orally to animals on which this tumor had been implanted. In later studies, lapachol was found to be active against other kinds of animal cancers, including Yoshida sarcoma and Murphy-Sturm lymphosarcoma."

15 A Lapachol Derivative Active Against Mouse Lymphocytic Leukemia P388 by M. da Consolamo et al. J Med Chem 18, 11, Nov. 1975, 1159-61. "Lapachol and its derivatives were tested against rat tumor Walker 256 carcinosarcoma and found to be active. It was also effective against mouse lymphocytic leukemia P388."

16 Herbal tonic Therapies by Daniel Mowrey. Keats Publishing, Inc., New Canaan, Connecticut, 1993. Pg. 70-89. "In vivo trials show definite inhibition of free radicals and the inflammatory leukotrienes by lapacho constituents. One of the strongest actions of lapacho is against viruses. Antiviral effects are seen against herpesvirus hominis types I and II, polio virus, vesicular stomatitis virus, avian mycloblastosis virus, murine leukemia virus, Friend virus, and Rous sarcoma virus. One factor, beta-lapachone, inhibits reverse transcriptase enzyme. Lapacho was found to be effective against both Schistosoma mansoni and Trypanosoma cruzi. Lapacho is often singled out as the premier treatment for Candida or yeast infections. Toe and fingernail fungal infections are relieved by soaking the appendages in lapacho tea of and on for a couple of weeks."

17 Comparative Hepatoprotective Activity of Three Phyllanthus Species, P. urinaria, P. niruri and P. simplex, on Carbon Tetrachloride Induced Liver Injury in the Rat by a A. Prakash, K.S. Satyan, S.P. Wahi, and R.P. Singh. Phototherapy Research Vol. 9, 594-596, 1995. "Pretreatment of animals with an alcoholic extract of P. niruri showed it had significant hepatoprotective activity at doses of 40mg/kg/day (p less than 0.05) and 400 mg/kg/day (p less than 0.01). Further, at the different doses administered, the extracts showed dose-dependent hepatoprotective activity."

18 In Vitro Studies on the Effect of Certain Natural Products Against Hepatitis B virus by Raj Mehrotra et al. Indian J Med Res 92, April 1990, 133-138. "Anti-HBs-like activity was observed in picroliv, picroside I, kutkoside, P. niruri extract and catalpol. Silymarin and andrographolide had little or no effect. The anti-HBs like activity of test compounds/extract was not affected by the presence of other HBV markers in serum samples and it did not interfere with HBsAg Elisa system used in the study." P. niruri affected 68% of the 27 serum samples tested. The effect of P. niruri against HBsAg was high (83%) in AVH and in serum samples from cirrhosis patients, as compared to HBsAg carriers (38%).

19 Protection Afforded by Aqueous Extracts of Phyllanthus Species Against Cytotoxicity Induced by Lead and Aluminum Salts by H. Dhir, A. Roy, A. Sharma and G. Talukder. Phytotherapy Research, Vol. 4, No. 5, 1990. "Oral administration of aqueous extracts of P. niruri leaves to laboratory bred albino mice for a week significantly reduced the cytotoxic action of lead nitrate and aluminum sulphate. The frequency of chromosomal breakages, gaps and rearrangements induced by three concentrations of these salts was decreased when compared to the control animals which had received the salts alone."

20 Antihepatotoxic Principles of Phyllantus niruri Herbs by K. Venkata Syamasunder et al, Jour of Ethnophara 14, 1985, 41-44. "Significant inhibitory actions were observed with phyllanthin and hypophyllanthin in preventing CC1-4-produced cell lesions."

21 In Vitro Inactivation of HBsAg by Eclipta alba Hassk and Phyllanthus niruri. Indian J Med Res 76 (Suppl) Dec 1982, 124-30. Researchers did an in vitro test to evaluate the in vitro immuno-inactivating ability of plants on hepatitis B surface antigen. When P. niruri roots and shoots were dried and powdered, the researchers "revealed a definite immunoinactive property of the plant against the surface antigen of hepatitis B virus. Further analysis by TLC indicated a red pigment uniformly present in all the parts of these plants to be the seat of such action."

22 Herbs of Genus Phyllanthus in Treatment of Chronic Hepatitis B: Observations with 3 Preparations from Different Geographic Sites. J Lab Clin Med 1995, 126: 350-352 "88 Patients with chronic hepatitis B were randomly assigned to get one of three herbs for three months. 0.3 gm three times a day for the first month; 0.6 gm three times a day for the second month; 0.9 gm three times a day for the third month. There were no obvious ill effects. The most striking and promising finding - substantial incidence of clearance of hepatitis B e-ag from serum as well as a substantial incidence of appearance of antibody to that antigen."

23 Hypoglycemic Action of Stevia Rebaudiana Bertoni by C.A. Oviedo, C. Ronciani, R. Moreo, and L.L. Maas. Excerpta Medica, Vol. 209, 92, 1970. These researchers reported anti-hyperglycemic actions of Stevia in 1970 and beneficial effects in the treatment of diabetes mellitus. Twenty-five healthy adults were given the dried aqueous extract orally. An average fall in blood glucose levels of 35.2% was noted between 6 and 8 hours later.

24 Efeito Hipoglicemiante De Stevia Rebaudiana Bertoni by M. Alvares, R.B. Bazzone, G.L. Godoy, R. Cury, L.M. Botion. 1st Brazilian Seminar on Stevia rebaudiana, 1981. Reprint of handout. In 1981 at the 1st Brazilian Seminar on Stevia rebaudiana, researchers presented findings on the hypoglycemic action of this herb. Fifteen human participants aged 19-25 years old took the equivalent of 1 gm stevioside per day, divided into 4 applications of 250 mg each, every 6 hours. The results showed an accentuated hypoglycemic response in the subjects studied.

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